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Dihydroavenatine (Nanaocalmin) has fast anti-inflammatory and antipruritic activity. Studies have shown that avenar alkaloids have multifunctional anti-inflammatory activities, including inhibiting the degradation of keratinocyte nuclear factor NF-κB-α, which is directly related to inflammation, and preventing the phosphorylation of p65 protein subunits on nuclear factor NF-κB, thereby preventing Cut off the process of cell inflammation; reduce the occurrence of inflammatory immune response and skin neurodermatitis.