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Why do we choose Alpha-GPC, not Beta-GPC?
Beta-glycerylphosphocholine(Beta-GPC) is also a member of phosphocholines.
Beta-GPC contributes very little to total GPC(~1%), while Alpha-GPC is hydrolyzed to phosphorylcholine and contributes to the supply of choline needed by the liver and choline needed for myelin synthesis.
How Does Alpha GPC work?
When the human body absorbs Alpha-GPC, it is decomposed into choline and glycerophosphate under the action of enzymes in the body. Among them, choline participates in the biosynthesis of acetylcholine, which is a kind of neurotransmitter; glycerophosphate is lecithin Derivatives, involved in the synthesis of lecithin.
The main pharmacological effects of Alpha-GPC include protecting the metabolism of choline; ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation; improving cognitive and behavioral responses in patients with traumatic brain capillaries.
From the source, Alpha-GPC can be obtained naturally from soybean lecithin, or it can be made by synthetic route; CDP Choline is mainly synthetic route; phosphatidylserine (PS) can be obtained from soybean lecithin, sunflower lecithin, etc.
In terms of efficacy, CDP Choline is mainly used as a brain metabolism and neuroactivator, which can promote brain cell respiration, improve brain function, enhance the function of the activation system of the ascending reticular structure, promote recovery, and reduce cerebrovascular resistance; Phosphatidylserine also It is called compound nervonic acid, which is an active substance of cell membrane. Its effect is to improve the function of nerve cells, regulate the conduction of nerve impulses, and enhance the memory function of the brain. Because of its strong lipophilicity, it can quickly enter the brain through the blood-brain barrier after absorption, soothe vascular smooth muscle cells and increase blood supply to the brain.
The three materials mentioned above are known for their cognitive benefits such as supporting memory, mental performance, and focus.
What are the Benefits of taking Alpha GPC?
Alpha-GPC is a widely used nootropic supplement, main benefits include:
Protect brain health
We all know that Alpha GPC is a precursor to acetylcholine, which enhances cholinergic transmission in the brain. Specifically through the mechanism of action Alpha GPC directly increases the synthesis and secretion of acetylcholine, better than any other choline-related compound, affecting choline concentrations system-wide and in the brain.
Alpha GPC can counteract brain aging by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural changes in the brain.
Alpha GPC also works to improve mental performance and improve memory and learning by counteracting the age-related loss of nerve cells and fibers in the brain.
High doses (1200 mg) of Alpha-GPC are effective in mild to moderate Alzheimer’s disease and work well with standard therapy (acetylcholinesterase inhibitors).
Boost muscle and athletic performance
Some preliminary evidence shows that Alpha GPC has the ability to support healthy brain function and the release of somatotrophin (hGH). it also is able to enhance acute growth hormone production and power output during exercise. Increased growth hormone production and power output can increase muscle mass and improve overall metabolic activity, thereby enhancing muscle and athletic performance.
Studies also report that slightly higher single doses of 600mg-800mg may be more beneficial when Alpha GPC is taken before exercise (such as a pre-workout supplement).
In summary, Alpha-GPC has two main functions:
- Central effect: improve dementia; improve learning ability; inhibit the secretion of stress hormones
- Peripheral effect: promote growth hormone secretion; improve liver function; immunity and repair ability during injury.
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